Acquisition of Endonuclease Specificity during Evolution of L1 Retrotransposon
نویسندگان
چکیده
منابع مشابه
Acquisition of endonuclease specificity during evolution of L1 retrotransposon.
L1 is the most proliferative autonomous retroelement that comprises about 20% of mammalian genomes. Why L1s have proliferated so extensively in mammalian genomes is an important yet unsolved question. L1 copies are amplified via retrotransposition, in which the DNA cleavage specificity by the L1-encoded endonuclease (EN) primarily dictates sites of insertion. Whereas mammalian L1s show target p...
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Human L1 elements are highly abundant poly(A) (non-LTR) retrotransposons whose second open reading frame (ORF2) encodes a reverse transcriptase (RT). We have identified an endonuclease (EN) domain at the L1 ORF2 N-terminus that is highly conserved among poly(A) retrotransposons and resembles the apurinic/apyrimidinic (AP) endonucleases. Purified L1 EN protein (L1 ENp) makes 5'-PO4, 3'-OH nicks ...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2007
ISSN: 0737-4038,1537-1719
DOI: 10.1093/molbev/msm130